The COVID-19 pandemic highlighted the urgent need for decentralized diagnostics and rapid point-of-care testing. In this presentation, efforts toward the development of affordable and accessible electroanalytical sensing technologies for at-home and on-body biochemical analysis will be presented. Soft, flexible sensors based on textiles, conductive yarns, and laser-engraved thin films are designed using principles of scalability, cost-effectiveness, and user-centered design. These platforms are engineered for the selective and reliable detection of biomarkers in complex biological fluids, including blood, saliva, and breast milk, enabling analytical performance outside traditional clinical laboratory settings. Recent advances in companion diagnostics for at-home monitoring of therapeutic drug levels, along with progress toward wearable platforms for continuous biochemical sensing, will be discussed. Particular emphasis will be placed on applications addressing critical unmet needs in mental health and women’s health, where patient-centric and decentralized technologies are expected to substantially expand access to care. Key challenges, including biofluid sampling strategies, burden-free sample collection, and approaches for mitigating sensor drift and calibration limitations, will also be addressed.
