Solventless Whole-Plant Extraction Using Inline Cavitation: A Scalable Path to Clean, Full-Spectrum Cannabis Extracts

Solventless extraction technologies are redefining the production of whole-plant cannabis and hemp extracts by eliminating reliance on conventional organic solvents and promoting cleaner, more sustainable manufacturing methods. This presentation explores the integration of inline cavitation as a disruptive, scalable solution for solventless extraction of whole-plant material. Inline cavitation, achieved through high-frequency ultrasonic or hydrodynamic devices, generates localized pressure differentials that rupture plant cell walls, efficiently liberating resinous compounds, cannabinoids, terpenes, and other bioactives into an aqueous or dry matrix. We will review the mechanism of cavitation, equipment requirements, and critical process parameters, including temperature, throughput, and feedstock preparation, while highlighting process safety, energy consumption, and regulatory advantages over traditional solvent and mechanical extraction systems. Comparative results from analytical testing (potency, terpene retention, and contaminant analysis) will be discussed, supporting that inline cavitation maintains whole-spectrum fidelity and minimizes thermal degradation or oxidation of target compounds. Discussion will consider integration potential with filtration, decarboxylation, and downstream formulation steps, enabling a continuous, closed-loop production model. This innovative, solventless workflow offers robust quality, scalability, and compliance advantages, positioning inline cavitation as a leading technique for next-generation, consumer-safe cannabis and hemp extracts.