Applied Maintenance & Troubleshooting of HPLC & LC-MS
Saturday, March 7, 2026 8:30 AM to 5:00 PM · 8 hr. 30 min. (America/New_York)
Short Course Office - Room 211
Short Course
Instrumentation & Nanoscience
Information
This course has been approved by the Royal Society of Chemistry (RSC) for purposes of Continuing Professional Development.
It looks in detail at:
The parts of the HPLC and LC-MS system requiring maintenance,
Going in depth into the frequency of maintenance operations
How to identify when maintenance is required.
Preparing for problems in HPLC and LC-MS
How to identify problems in the system
Step-by-step troubleshooting process
Participants will consolidate their knowledge gained through practical exercises. Overall, there is a strong emphasis on the practical aspects of HPLC and LC-MS, with instrument parts to observe and handle.
It looks in detail at:
The parts of the HPLC and LC-MS system requiring maintenance,
Going in depth into the frequency of maintenance operations
How to identify when maintenance is required.
Preparing for problems in HPLC and LC-MS
How to identify problems in the system
Step-by-step troubleshooting process
Participants will consolidate their knowledge gained through practical exercises. Overall, there is a strong emphasis on the practical aspects of HPLC and LC-MS, with instrument parts to observe and handle.
Day of Week
Saturday
Session Number
SC-7352
Application
Instrumentation
Methodology
Liquid Chromatography/LCMS
Primary Focus
Application
Short Course Information
Course Level
Intermediate
Duration
Full Day Course
Learning Objective
You will learn about each part of the instrument requiring maintenance and why, when maintenance is required and how frequently maintenance is required for each instrument part and consumable.
You will learn the logical steps of instrument troubleshooting.
You will learn how to examine chromatograms, identify any problems seen and determine which part of the instrument could be the cause and gain practical experience of this process.
Course Outline
The course covers in detail the parts of the system requiring maintenance and the logical steps of troubleshooting, covering:
LC Maintenance:
Injectors
Columns
Detectors
Valves and seals
MS Maintenance:
Gas supply & plumbing
Vacuum system
Data system maintenance
Maintenance schedules
Troubleshooting areas:
Problem samples
Problem analytes
Problem areas:
Mobile phase
LC pump
Autosampler
Column
Sensitivity
Retention time shift
Contamination
Mass spectrometer vacuum
Chromatogram examination
Target Audience
This course is for those with good knowledge of liquid chromatography and liquid chromatography-mass spectrometry and would like to learn in detail about maintenance and troubleshooting.
Early Fee (before Jan 29, 2026)
$900.00
Full Fee (after Jan 29, 2026)
$1100.00
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