Overcoming Challenges Presented by Metal Surfaces in Pharmaceutical Analysis from Discovery to Clinical Applications

Metal surfaces, specifically stainless steel, in liquid chromatography systems can cause a myriad of issues for pharmaceutical analysis. While corrosion issues and the introduction of metal species into the analytical flow path can be a lead to issues, a larger concern is the binding or chelating of metal sensitive analytes. This non-specific adsorption effect typically occurs between acidic analytes and metal surfaces and can cause roadblocks for method development and routine analysis. This becomes more concerning when critical impurities and trace amounts of analyte are measured. Many options exist for overcoming this problem. Changing the metal alloys, utilizing PEEK, coating the stainless steel with a bio-inert coating, utilizing chelating agents to protect the sensitive analytes are all options at the disposal of scientists. In this session, we will bring a variety of speakers to share their solutions to metal surfaces and non-specific adsorption, including presentations on discovery and development, impurity quantification, scaling from analytical to prep methods, and omics.