S15: Harnessing synaptic mechanisms and network dynamics to tackle neurodegenerative disorders
Information
Convened by CURE-ND
CURE-ND (Catalysing a United Response in Europe to Neurodegenerative Diseases) is an alliance of four world-leading research institutions across Europe (UK Dementia Research Institute (UK DRI), the German Center for Neurodegenerative Diseases (DZNE), Mission Lucidity (Belgium), and Paris Brain Institute (ICM) promoting collaboration across borders to tackle neurodegenerative disorders.
Synaptic and neural circuit dysfunction are early pathological features of neurodegenerative disorders, such as Alzheimer’s disease (AD), leading to dementia, offering opportunities to develop disease-modifying therapies. This symposium aims to explore how synaptic mechanisms and circuit dynamics can be harnessed to better understand the initial phase of devastating neurodegenerative disorders and to devise new therapeutic interventions. Speakers will discuss mechanisms underlying synaptic/circuit dysregulation in neurodegenerative diseases and how these can pave the way for new treatments. Research strategies include human studies, animal and in vitro models, and AI-enabled data integration.
Dr Raffaella Migliaccio (ICM-Paris Brain Institute), will discuss changes in brain connectivity in patients with neurodegenerative diseases drawing on structural and functional MRI data, and behavioural assessment studies.
Dr Carola Radulescu (UK DRI) will present novel insights from mouse models into homeostatic mechanisms that may prevent early AD-related hyperactivity.
Dr Dennis Lambrechts (Imec-Mission Lucidity) will discuss how pioneering semiconductor technology, like brain-on-chip, can advance human models for both neurodegeneration research and drug delivery strategies.
Finally, Brett Emery will describe an innovative AI-enabled platform for multimodal data integration to decode the intricate dynamics of neural circuits and its applications to biomarker and drug discovery.
- Co-Chair: Dr Raffaella Lara Migliaccio - Changes in brain connectivity in neurodegenerative diseases
- Co-Chair: Dr Carola Radulescu - Age and amyloid-related dysregulation of micro-circuit homeostasis
- Dr Dennis Lambrechts - Imec-Mission Lucidity, Belgium: How nanotechnology can enable a future without brain disease
- Brett Emery - Multiscale Translational Platform for Predictive Brain Circuit and Drug Discovery
Speakers
