Cell based assays (infectious disease testing, and more)

Well-designed cellular assays represent the key to any successful preclinical or clinical program and can make the difference between a cost efficient, direct path to IND and a convoluted, expensive development path wrought by ill-informed decisions, repeats and setbacks. High quality cellular data are key to identifying, screening and validating candidates through all stages of development from discovery to safety, immunogenicity and efficacy studies. As a leading CRO in cell based assays, ABL offers: • Sample testing in support of both preclinical and clinical programs • Expert advice on the most relevant and applicable cellular methods • Custom assay development, method transfer and fit-for-purpose method validation • State-of-the-art instrumentation to accommodate the latest techniques ABL’s expertise in cellular assessments includes: • T and B cell ELISpot • FluoroSpot • Immunophenotyping • T/B/NK Cell Enumeration • Intracellular Cytokine Staining (ICS) • Tetramer and Multimer Staining • Lymphoproliferation • Neutralizing Antibody (NAb) assays • Antibody Dependent Cell-mediated Cytoxicity (ADCC) • Complement Dependent Cell Cytoxicity (CDC) • Antibody-mediated Opsonization / phagocytosis ABL scientists support and strengthen our clients’ programs such as: • Target selection • Lead optimization • Preclinical development • Proof of Concept • Dose determination • Mechanism of action • Combination therapies • Immunogenicity • Efficacy