QS-21

QS-21

Pharma

Information

Quillaja saponaria Molina is a South American tree native to Chile whose bark is rich in a complex mixture of triterpenic saponins. Quillaja-derived saponins, such as Quil-A®, are currently used as veterinary vaccine adjuvants. One specific fraction of the Quil-A saponin mixture, QS-21, is an extremely potent adjuvant with potential use in a broad variety of vaccines. It has been shown to enhance antibody- and cell-mediated immune response and has been investigated for human vaccine applications. QS-21 possesses an optimal balance of low toxicity and high immunostimulatory efficacy, and has already been used in one commercialised vaccine.
CrodaCroda International Plc, a specialty chemical company providing high purity and high quality excipients for drug and vaccine development, has recently strengthened their offering with the acquisition of a line of vaccine adjuvants. Providing customers with over 80 years of adjuvant expertise, Croda Vaccine Adjuvants (formerly Brenntag Biosector) has unprecedented industry experience as a vaccine adjuvant specialist. In addition to supplying industry renowned aluminium- and saponin-based adjuvants, including the well-known brands Alhydrogel®, Adju-Phos® and Quil-A®, Croda is committed to developing the next generation of adjuvant technology, with a robust innovation pipeline focusing on enhanced protein binding and immune-stimulating nanotechnology.

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