Advantages of Standardization and Large-scale Manufacturing of Helper Plasmids for Viral Vector Production

Aldevron has developed processes to quickly produce a set of helper plasmids that consistently generate functional viral vectors, are immediately available for research and clinical production. Standardization of lentiviral plasmids supports consistency and efficiency at large scale and across multiple programs. Our data show the scalability of fermentation for a typical plasmid at 30 L and 300 L, with specific yield maintained as scale is increased. The data show the performance of lentiviral vectors produced with optimized plasmids, indicating improved performance over other plasmid systems. The availability, cost, freedom to operate, and consistency of these plasmids will help address the growing demands of cell and gene therapy. You can download a full PDF version at https://bit.ly/39u1k9M