Manufacturing CRISPR RNPs for Clinical Applications

Manufacturing CRISPR RNPs for Clinical Applications

Poster Zone

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Aldevron specializes in manufacturing Cas9 proteins, as well as custom protein development and manufacturing services. Although many vendors offer research-grade CRISPR/Cas nucleases, these are not applicable to clinical programs due to construct design and quality grade. While Aldevron is the only manufacturer to offer GMP-grade Cas9 proteins and select vendors offer GMP-grade synthetic single guide RNAs (sgRNAs), there are currently no options for complexing the two as a ribonucleoprotein (RNP) in a GMP-certified process. In an effort to address this gap in manufacturing for therapeutic genome editing, Aldevron has created a method to complex, QC, and characterize RNP complexes under GMP conditions. Poster is a narrated presentation with option to download full PDF version. View it here: https://youtu.be/Kkca3BNjHy4
AldevronLatest News: Aldevron Ranked Number 287 Fastest-Growing Company in North America on Deloitte’s 2020 Technology Fast 500™  Founded in 1998, Aldevron serves the biotechnology industry with custom production of nucleic acids, proteins, and antibodies. Thousands of clients worldwide rely on Aldevron-produced plasmid DNA, RNA, gene editing enzymes and more for biological research projects from discovery to clinical trials and commercial applications. These efforts help accelerate development of treatments for diseases such as cancer, infectious disease, pediatric disorders and rare diseases. Aldevron specializes in cGMP manufacturing and is known for inventing the GMP-Source® quality system. Our mission is to be a partner in the development of medicines that improve patients’ lives while serving clients, employees, and the community, while constantly looking for new and better ways to give researchers the products and services they need. Aldevron operates the largest cGMP plasmid DNA manufacturing facility in the world, located in Fargo, North Dakota, which serves as company headquarters, with additional production facilities in Madison, Wisconsin.  What can we do for you? Learn more about our products and services on our website  Watch our continuing growth as our campus expands!  Want to join the fastest growing biologics manufacturer in the region? Aldevron is hiring! 

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