Bioinformatics Platform- Cytographer®

Bioinformatics Platform- Cytographer®

Bioanalytical & Data

Information

Cytographer® enables the processing, analysing and visualising of high-dimensional single cell data, including the screening and identification of antigen-specific T cells, to generate meaningful biological insights and correlations with clinical parameters. Cytographer® can support CyTOF, flow cytometry and RNAseq datasets, and incorporates methodologies and tools for high-throughput processing, high-dimensional data reduction, immune subset detection, statistics and correlations analysis, as well as state of the art algorithms for biomarker discovery.
ImmunoScapeImmunoScape is a biotechnology company focused on immunotherapy and leveraging a unique high-dimensional immune profiling platform. We work with BioPharma and academic partners to conduct deep cellular immunoprofiling across different domains, including infectious diseases, vaccines and oncology. Using mass cytometry and proprietary metal-tagged barcoded tetramers, we have the capacity to identify 100's of antigen-specific T cells in a single sample whilst simultaneously looking at 35+ phenotypic markers.  ImmunoScape is working extensively in the COVID-19 space (i) assessing vaccine-induced immunity to COVID-19 vaccines, (ii) deeply characterizing SARS-CoV-2-specific T cell responses in COVID-19 patients, and (iii) assessing the evolution of immunity in COVID-19 patients on treatment regimens. We have set up a panel of 400 SARS-CoV-2 epitopes and a 30-marker CyOTF panel to screen and characterize epitope usage and the associated cellular phenotype in COVID-19 patients.  To help vaccine development companies assess their COVID-19 vaccine candidates, ImmuoScape tailors it's analytical strategy to analyze the magnitude and quality of the relevant vaccine-induced immune response over time.

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