Protecting Heart Health with hERG Inhibition Prediction
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Developing safe medicines is hard work. Researchers must rigorously assess every drug candidate molecule to ensure it does not harm patients. Cardiotoxicity – toxicity to the heart – is one of the factors that scientists consider.
Members of the ACD/Labs team, Kiril Lanevskij, Remigijus Didziapetris, and Andrius Sazonovas recently published a paper on the subject of predicting hERG inhibition, a property critical for assessing cardiotoxicity. This conversation with Andrius and Kiril discusses what hERG inhibition is, and how they were able to build a model using the unusual data available.
