T cell binding avidity predicts optimal anti-tumor response

• The strength of binding between a CAR/TCR and cognate ligand, through quality and quantity of signaling, can dictate downstream cell function
• Quantifying cell avidity with acoustic force gives a direct and predictive parameter for characterizing optimal TCR-T and CAR-T function
• Tuning the affinity, and thereby avidity, of CAR-T scFv's can increase the persistence of CAR-T's in-vitro and in-vivo- 
• Discuss the mechanism by which different endo-domains can alter binding kinetics to tumors

 Will Singleterry, Commercial Director  –  Immuno-Oncology, Lumicks