Moving beyond conventional analytical approaches to uncover what your antibody hides from you

Moving beyond conventional analytical approaches to uncover what your antibody hides from you

Tuesday, March 30, 2021 3:00 PM to 3:20 PM · 20 min. (Africa/Abidjan)
Antibodies
New technology in screening & analytics
Presentation

Information

  • Proteins have personalities which are governed by physico-chemical properties
  • These influence behaviors such as self-association and propensity to aggregate which can impact on safety, efficacy and long term stability
  • Monitoring such properties can be challenging but is critical to the development of suitable formulations from commencing early process development through to manufacturing
  • This case study for an engineered monoclonal antibody shows how sub-visible particle analysis, composition gradient multi-angle light scattering and dynamic light scattering reveal features which may be missed by other biophysical techniques

Francisco Gonzalez, Associate Principal Scientist Analytical and Formulation Development, FUJIFILM Diosynth 

FUJIFILM Diosynth BiotechnologiesFUJIFILM Diosynth Biotechnologies is an industry leading cGMP Contract Development and Manufacturing Organization (CDMO) supporting our partners in the biopharmaceutical industry with the development and production of their biologic, vaccines and gene therapies.  With over 30 years of experience in process development and cGMP manufacturing, a dedicated staff of over 2,000 and a reputation for excellent customer service, flexibility and responsiveness, we’ve become a trusted partner to some of the most prominent biotech developers and pharmaceutical companies in the industry.  Our Process Development experience includes the development of processes for molecules expressed via fermentation (e.g., E. coli, P. pastoris), cell culture systems including CHO, HEK, Vero, MDCK, EB66 and insect cells, and from transgenic sources.  Our network expands within four development and manufacturing facilities located in Teesside, United Kingdom; Research Triangle Park, North Carolina, USA; College Station, Texas, USA and Hillerød, Denmark.  

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