Unraveling the function of CLE peptides in JA induction caused by cell wall damage

Cell wall damage (CWD) is detected by receptor kinases and ion channels, triggering downstream signaling pathways involving calcium release, gene expression changes, reactive oxygen species and phytohormone production, influencing CW structure and composition. This study aims to unravel the regulatory mechanisms responsible for jasmonic acid (JA) induction in response to CWD using an integrated approach (incorporating RNA-seq, phosphoproteomics, and phenotypic analysis of different mutants). The results of this study have implicated involvement of CLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides, as JA levels are significantly lower in certain cle mutants compared to wild-type seedlings after CWD exposure.