Cyst nematodes counteract immunity by inhibiting activation of central nodes of a Solanaceae immune network

Plant pathogens deploy effectors that suppress plant immune responses and promote disease. Despite their important role in pathogenicity, our understanding of the mechanisms underlying effector function remains relatively limited. We previously identified SS15 – a SPRYSEC-type effector derived from the potato cyst nematode Globodera rostochiensis – as a potent suppressor of immunity in Solanaceous plants. SS15 targets the function of helper NLRs, NRC2 and NRC3, that are central nodes of a complex immune signalling network. Here, we will present our latest findings on SS15 and how we can utilise our mechanistic understanding of effector biology to engineer resistance in crops.