New Approaches to Capillary LC Column Development

As greener approaches to chemical analysis continue to grow in popularity, the significant decrease in mobile phase flow rates makes capillary LC an appealing choice for liquid chromatographic separations. In this presentation, recent advances in capillary LC column design will be described. The use of a “tube-in-manifold” design to enable circular cross-section columns within microfluidic column formats improves column loading and performance for integrated column chips. Integrated column cartridges where a column, heater, and detector are combined within a single unit promote ease-of-use for capillary LC, especially within miniaturized systems. Descriptions of various stationary phases used in these column formats will also be presented.