Exploring the Impacts of Different Types of Carbon Application During Per- and Polyfluoroalkyl Substances (PFAS) Extraction Following EPA Method 1633

EPA method 1633A is a performance-based analytical method validated for targeted quantification of per- and polyfluoroalkyl substances (PFAS) across diverse environmental matrices. Complex sample matrices can increase preparation time and require additional cleanup to remove interferences to ensure accurate results. In this study, we evaluated alternative sample preparation strategies across multiple matrices to reduce interferences while improving efficiency and accuracy (or precision if you prefer). Specifically, workflows utilizing loose graphitized carbon black (GCB) and stacked carbon cartridges were assessed for their performance in processing PFAS compounds. The analysis accounted for the varied physicochemical properties of the different PFAS classes to optimize method performance and data quality.