256: Resin-Based green catalysis for efficient synthesis of Lobophopyranone A

Abstract: Resin-derived heterogeneous catalysis have emerged as an effective approach in organic synthesis for devising sustainable methods and products. Microwave reactors have also emerged as an attractive option for synthesis due to the potential for higher yields, faster reaction times, and energy efficiency. This study explores the use of Amberlite (a proton-exchange resin) as a heterogeneous catalyst for the cyclization of δ-hydroxyalkynones into bioactive 4H-pyranones under metal-free conditions. The total synthesis of the natural product lobophopyranone A was The resin-derived heterogeneous catalysis can serve as an exemplary green catalyst, offering notable advantages such as atom economy, catalyst recovery, reusability, and effectiveness.