Downstream processing in biochemical manufacturing

In the chemical or bioprocess engineering industry, products must be separated from a complex media mixture and freed from impurities. This is an important step in the entire chain of downstream processing to guarantee a product with the required purity. The stationary and mobile phase of liquid chromatography The precise and safe purification of substances using chromatography is an essential step in the manufacture of fine chemicals. For this purpose, a bio-physical principle is applied which takes advantage of the various flow properties and flow velocities of the components. The individual components are separated between a stationary phase (the tubular column in a column) and a mobile phase, which flows through the stationary packing (in this case a liquid). Operation principle of chromatography To purify (downstream processing) a liquid from various components, it is fed into a chromatography process. Due to the various velocities at which all liquids are pumped through the plant, the individual components can be separated as a result of the different flow properties and varying interactions between the stationary and the mobile phase of the substances. Why is chromatography so important? It can be used to separate complex media mixtures with great precision. Even very complicated molecules such as proteins can, e.g., be gently separated from each other using chromatography. Under no circumstances should contamination or mixing of media occur. Choice of the right valve is a decisive factor here, as it controls and distributes the media into and out of the chromatography column – precisely and efficiently. Designed for the control of ultra-pure, sterile and aseptic media, the Robolux Multiway Diaphragm Valve Type 2036 offers the ideal solution for chromatography processes.