D-Dimer, PCT, CRP, SAA and IL-6 inflammation markers


D-dimer is a specific degradation product of fibrin monomer which is cross-linked by activated factor XIII and then hydrolyzed by plasmin. It is a specific fibrinolytic process marker. The D-dimer is derived from a plasmin-dissolved cross-linked fibrin clot. The most important clinical value of D-dimer detection is used for excluding venous thrombotic diseases, and also for the diagnosis of disseminated intravascular coagulation, and for the monitoring of thrombolytic therapy. Interleukin 6 (IL-6) is an important member of the cytokine network, which is produced by fibroblasts, monocytes/macrophages, T lymphocytes, B lymphocytes, epithelial cells, keratinocytes, and various tumor cells . It plays a central role in the acute inflammatory response, mediating the acute phase response of the liver and stimulating the production of C-reactive protein (CRP) and fibrinogen. A variety of infectious diseases can lead to increased serum IL-6 levels, and IL-6 levels are closely related to patient prognosis. The combination use of D-Dimer and IL-6 can be helpful to monitor the infected patient situation and help the clinical doctors make treatment plan.