Bruker IVDr Lipoprotein Subclass Analysis: B.I.LISA


Lipoprotein distributions play a major role in cardiovascular risk assessment, while the main fractions HDL = High Density Lipoprotein IDL = Intermediate Density Lipoprotein LDL = Low Density Lipoprotein VLDL = Very low Density Lipoprotein And the typical house doctor`s panel Total Cholesterol Total Triglyceride LDL Cholesterol HDL Cholesterol can be readily obtained by conventional analysis, subfractions of LDL, HDL and VLDL is best measured by NMR. In the Literature various publications show, that subfractions, especially LDL and HDL cholesterol, can produce better risk analysis, they are also carry information in various types of cancer. B.I.LISA produces 115 parameters, including e.g. Particle numbers, APO A1, APO B and APO A2, cholesterol, free cholesterol, triglyceride and phospholipid main and subfraction values. The values are obtained by NMR regression training on ultracentrifugation results of a representative human cohort. Ultracentrifugation is considered the gold standard in the subclass analysis, however the total analysis time is about 1 week, while NMR does this in 10 minutes. (For research use only)